Liang,Bowen
Vol. 2, Issue 1, Pages: 46-51(2025)
Doi：https://doi.org/10.62639/sspjinss08.20250201
ISSN：3006-0729
EISSN：3006-4287
55
Downloads：3
As one of the most important proteins in plasma, human serum albumin (HSA) has multiple physiological functions, such as maintaining osmotic pressure, transporting endogenous and exogenous substances, and immunomodulation. However, with the increasing clinical use and relative shortage of plasma raw materials, the shortage of supply and price of HSA have gradually become more and more obvious. Recombinant Human Serum Albumin (rHSA) has received extensive attention in the field of pharmacy due to its advantages of avoiding blood contamination, controllable production capacity, and high quality consistency. The rHSA expressed by genetic engineering technology has already emerged in industrial production, clinical research, drug carriers and other aspects, and many domestic and foreign companies are laying the groundwork for the industrialization of related products. In this study, the structure and function of recombinant human serum albumin, preparation technology, clinical application prospect, quality control and industrialization process are systematically described with reference to the literature and practical progress in recent years, and the future development direction of the recombinant human serum albumin is prospected.
KeywordRecombinant human serum albumin;Pharmacological applications;Plasma